Supplier and Substance Identification Product Information Product name: Toluene Diisocyanate Description: Polyurethane component, industrial chemicals Recommended use of the chemical and restrictions on use Recommended use Plasticizer Uses advised against None known Supplier: The Chemical Company 44 Southwest Avenue … * Toluene-2,4-Diisocyanate will polymerize and rupture containers at temperatures over 350oF (176.5oC). Toluene is also called as toluol, is an aromatic hydrocarbon. 2,4-Toluene diisocyanate . Isocyanates also react with amines to give ureas: R … This site is not fully supported in Internet Explorer 7 (and earlier versions). * Toluene-2,4-Diisocyanate reacts with WATER releasing Carbon Dioxide gasand HEAT which may cause containers to rupture. Belongs to the Following Reactive Group (s) Toluene diisocyanate - 1 Toluene diisocyanate (1,3-Diisocyanatomethylbenzene, 2,4- and 2,6-Toluene diisocyanate, ... atmosphere by reaction with photochemically-produced hydroxyl radicals with an estimated half-life of 2.7 days for the mixed isomers, 1.7 days for 2,4-TDI, and 2.5 days . The Support section provides tools and practical guidance to companies which have responsibilities under the EU chemicals legislation. The per substance REACH registration status is being calculated and will be made available as soon as possible. Other . Toluene diisocyanate is miscible with many organic solvents, but it is almost insoluble in water. By continuing you agree to the use of cookies. Whatever the role of toluenediamine in the adverse respiratory effects induced by exposure to isocyanates, our findings reveal the necessity of in vivo studies on the metabolism of inhaled toluene diisocyanate in humans to improve our understanding of the mechanism of action of isocyanates. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. [Handling Chemcials Safely 1980. p. 907]. This website uses cookies to ensure you get the best experience on our websites. Glutathione has previously been identified as a reaction target for toluene diisocyanate (TDI) in vitro and in vivo, and has been suggested to contribute to toxic and allergic reactions to exposure. Substances indicated, in 2009, as being intended to be registered by at least one company in the EEA. The reaction is exothermic and releases 47 kcal/mol of water. Pre-Registration process . Toluene diisocyanates react with water and most acids to produce polymeric urea. Toluene can also be used as a recreational inhalant sometimes, and it also has the potential of causing severe neurological harm. : 500-299-2. Manipulation 6 29 30. p-Toluenesulfonyl isocyanate undergoes palladium-catalyzed bis-allylation reaction with allylstannanes and allyl chlorides. It covers their hazardous properties, classification and labelling, and information on how to use them safely. The reaction of PTSI with water introduced from pigments and solvents in the paint formulation generates carbon dioxide and solu‐ ble inert chemical products. La nitration du toluène en présence de l'acide sulfurique est une réaction qui peut être violente. Here you can find all of the regulations and regulatory lists in which this substance appears, according to the data available to ECHA. Brief Profile REACH registered substance factsheets C&L Inventory Biocidal active substance factsheets PACT tool Regulatory Obligations . Please upgrade your Internet Explorer to a newer version. Preparation and Formation Mechanism of Porous Polyurea by Reaction of Toluene Diisocyanate with Water and Its Application as Adsorbent for Anionic Dye Removal* Shu-sheng Lia, b, Hui Hana, Xiao-li Zhua**, Xu-bao Jianga and Xiang Zheng Konga** a College of Chemistry and Chemical Engineering, University of Jinan, Jinan 250022, China TDI, both 2,4- and 2,6-toluenediamine (TDA) and mixtures of 2,4- and 2,6-TDA (ratio 80:20 and 20:80) caused concentration-dependent contraction in the isolated bronchi. Reaction of Isocyanate with Urea: Urea may form from the Mise à jour : 2017-04-06 . This reaction is exploited in tandem with the production of polyurethane to give polyurethane foams. MDI is highly reactive in the environment or when taken up by organisms and is rapidly hydrolysed to form 4,4’-methylenedianiline (MDA), which reacts with excess MDI to yield insoluble oligoureas and polyureas. Toluene diisocyanate (TDI) is an aromatic diisocyanate.It is produced for reaction with polyols to form polyurethanes.It exists in two isomers, 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). The Prior Informed Consent Regulation administers the import and export of certain hazardous chemicals and places obligations on companies who wish to export these chemicals to non-EU countries. Its insolubility in water may be important with respect to the fate of TDI upon inhalation. Our results provide evidence that all products of the reaction between toluene diisocyanate and water have the ability to contract isolated bronchial smooth muscle in guinea pigs. Mol. Toluene-2,4-diisocyanate IUPAC name 2,4-diisocyanato-1-methyl-benzene Other names Tolylene diisocyanate Methyl phenylene diisocyanate Identifiers CAS number 86-91-9: RTECS number CZ6300000 SMILES c1(C)c(N=C=O)cc(N=C=O)cc1: Properties Molecular formula C 9 H 6 N 2 O 2: Molar mass 174.2 g/mol Appearance Colorless to pale yellow, liquid Density 1.214 g/cm 3, liquid Melting point 21.8 °C … REACH regulation aims to improve the protection of human health and the environment from the risks that can be posed by chemicals. These can be biodegraded by treatment with activated sludge. Occupational exposure limit (OEL) values are derived within two legal frameworks that form an integral part of the EU’s mechanism for protecting the health of workers. Reaction with water liberates carbon dioxide. The CLP Regulation ensures that the hazards presented by chemicals are clearly communicated to workers and consumers in the European Union through classification and labelling of chemicals. Potential explosion if stored in polyethylene containers due to … It is colorless, water-insoluble and has a smell associated with paint thinners. Copyright © 2021 Elsevier B.V. or its licensors or contributors. Prendre connaissance des renseignements inscrits sur l'étiquette et la fiche de données de sécurité avant de manipuler ce produit. 1.2.3.4 Isocyanates. This is unique source of information on the chemicals manufactured and imported in Europe. The blowing reaction (3), of isocyanates with water, results in urea formation and carbon dioxide gas release. This reaction is very important in PU foam production. Substances listed in the EINECS, ELINCS, or NLP inventories. The polymerization reaction of toluene diisocyanate (TDI) and hydroxyl compounds has been widely used for the production of polyurea … 1,3-diisocyanato-2-methylbenzene; 2-(2-hydroxyethoxy)ethan-1-ol; 2-ethyl-2-(hydroxymethyl)propane-1,3-diol . Kinetics of water–isocyanate reaction in N , N -dimethylformamide. The experiments were performed in isolated guinea pig bronchi. PHOSGENE‐FREE ROUTE TO TOLUENE DIISOCYANATE Abstract A Gulf Coast production plant was designed for a phosgene-free route manufacture of 2,4-toluene diisocyanate (TDI) from toluene diamine (TDA). IUPAC names . 2,4-Toluene diisocyanate is extremely toxic from acute (short-term) and chronic (long-term) exposures. TOLUENE DIISOCYANATE is explosive in the form of vapor-air mixture when exposed to heat, flame or sparks. Help Key datasets. c) continuously mixing the mixture containing toluene-diisocyanate and the distillation residue of toluene-diisocyanate with water, at a temperature of less than 230° C. under an absolute pressure of less than 30 bar, and allowing said mixture to react under the same conditions (i.e. : 110839-12-8. Toluene diisocyanate, oligomeric reaction products with 2,2'-oxydiethanol and propylidenetrimethanol . 292 Toluene diisocyanate Toluene diisocyanate (TDI) is usually used as a technical grade mixture of isomers. PMDI is a dark reddish brown liquid with an indefinite melting point around 0 °C and a vapour pressure of <1 mPa at 20 °C. Recommendable methods: Incineration, alkaline hydrolysis, discharge to sewer. CAS no. L'exposition à ce produit requiert de la formation et de l'information préalables. Copyright © 1992 Published by Elsevier B.V. European Journal of Pharmacology: Environmental Toxicology and Pharmacology, https://doi.org/10.1016/0926-6917(92)90018-8. We have investigated the ability of the products of the reaction between toluene diisocyanate (TDI) and water to contract bronchial smooth muscle. ScienceDirect ® is a registered trademark of Elsevier B.V. ScienceDirect ® is a registered trademark of Elsevier B.V. Approximately 1.4 billion kilograms were produced in 2000. * n-octanol/water distribution coefficient. The carbon dioxide functions as a blowing agent. Regulatory process names 2 Other names 1 Other identifiers 3 . 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It is produced on a large scale, accounting for 34.1% of the global isocyanate market in 2000, second only to MDI. Application p-Toluenesulfonyl isocyanate has been used as : • derivatization reagent in determination of 3-α-hydroxy tibolone in human plasma by LC-MS/MS Major products of combustion/pyrolysis When heated to decomposition TDI emits toxic fumes of oxides of nitrogen (Sax and Lewis, 1989). Formula: C26H20N6O5 . Addition of base to water increase the rate of reaction with TDI, since the base abstracts the proton forming hydroxyl. What is the Classification and Labelling Inventory? Registration, Evaluation, Authorisation and Restriction of Chemicals, Chemical Agents Directive and Carcinogens or Mutagens Directive, Benzene, 1,3-diisocyanatomethyl-, homopolymer, Toluene diisocyanate, oligomeric reaction products with water, benzene, 1,3-diisocyanatomethyl, homopolymer, EC Inventory, Pre-Registration process, Other, Substances of very high concern identification, Recommendation for the Authorisation List, Getting started with EU chemicals legislation, Classification of substances and mixtures, Harmonised classification and labelling (CLH). Reaction with aniline may generate enough heat to ignite unreacted portion and surrounding materials. This substance has been found in the following regulatory activities (directly, or inheriting the regulatory context of a parent substance): Welcome to the ECHA website. We apologise for the inconvenience in the meantime. BPR regulation aims to improve the functioning of the biocidal products market in the EU, while ensuring a high level of protection for humans and the environment. Toluene diisocyanate, oligomeric reaction products with water . Because of the high reactivity of TDI /toluene diisocyanate/ waste waters contain only reaction products from the reaction with water. TOLUENE-2,6-DIISOCYANATE reacts violently with amines, alcohols, bases and warm water, causing fire and explosion hazards. Potentially violent polymerization reaction with strong bases or acyl chlorides. Toluene diisocyanate (TDI) is an organic compound with the formula CH3C6H3(NCO)2. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. Author information: (1)Mass Spectrometry Division, Korea Basic Science Institute, Cheongwon, Korea. As the temperature increases the reaction becomes more vigorous, but the vapours increases. Two of the six possible isomers are commercially important: 2,4-TDI (CAS: 584-84-9) and 2,6-TDI (CAS: 91-08-7). 1.2.1.3 - Reaction with water . Reaction monitoring of toluenediisocyanate (TDI) polymerization on a non-mixable aqueous surface by MALDI mass spectrometry. Johannes Karl Fink, in Reactive Polymers Fundamentals and Applications (Second Edition), 2013. The mixture of distributed urea and biuret also contracted the bronchi, but not in a concentration-dependent fashion. 1989]. Hazard Summary . The reaction rate of TDI with water at temperatures less than 500C is very low. 584-84-9 . REACH registered substance data was upgraded on 9th November. The POPs Regulation bans or severely restricts the production and use of persistent organic pollutants in the European Union. The products of the reaction between toluene diisocyanate and water contract isolated guinea pig bronchi. [Handling Chemcials Safely 1980. p. 907]. TDI, 2,4-TDI, 2,4-Toluene diisocyanate Colorless to pale-yellow solid or liquid (above 71°F) with a sharp, pungent odor. In fact, because of its insolubility in water, hydrolysis of TDI in the respiratory tract may be slow. Explosion limits For 2,4 TDI Concentration (% v/v) lower 0.9% upper 9.5% Boiling point At 760mmHg 251° C At 10mmHg 120° C for 2,4-TDI 121° C for commercial mixture Density (g/cm We use cookies to help provide and enhance our service and tailor content and ads. 2,4-TDI is produced in the pure state, but TDI is often marketed as 80/20 and 65/35 mixtures of the 2,4 and 2,6 isomers respectively. SAFETY DATA SHEET Revision Date 21-Feb-2020 Revision Number 2 1. Toluene Diisocyanate Revision Date: 06-June-2017 Version 1.1 1. EC / List no. For example, they can react with compounds containing active hydrogen atoms, like amines, alcohols, mercaptanes, water, and carboxylic acids or they can react with themselves to form dimers (uretdiones) and trimers (isocyanurates) or they can be polymerized to polyisocyanates (N-substituted 1-nylons). The structure of the material is characterized by Fourier transform infrared (FTIR), NMR It is first isolated in 1837 by distillation of pine oil by a Polish chemist named Filip Walter. It is possible that immiscible isocyanates may retain … The process was designed to generate 300 million pounds of TDI per year within the required process specifications. 1989]. Isocyanates react with water to form carbon dioxide: RNCO + H 2 O → RNH 2 + CO 2. Porosimetric tests demonstrate that PPU possesses typical properties of porous materials. Catalytic Effects of Water Clusters on the Hydrolysis of Toluene-2,4-diisocyanate: A DFT Study. Help Regulatory context. Reaction with water to form Carbon Dioxide [Merck 11th ed. All isomers of … Ahn YH(1), Kim JS, Kim SH. Porous polyurea (PPU) is prepared through a simple protocol by reacting toluene diisocyanate (TDI) with water in a binary solvent of water–acetone, and the process is optimized. Acute exposure to high levels of 2,4-toluene diisocyanate in humans, via inhalation, results in Health Hazards & Protective Measures. Toluene diisocyanate - 3 for the 2,6-isomer. The absolute rate of hydrolysis of TDA isomers is unknown. 2,4-Toluene diisocyanate is primarily used as a chemical intermediate in the production of polyurenthane products. Close Find out more on how we use cookies. Reaction with water to form Carbon Dioxide [Merck 11th ed. The carbon dioxide diffusion to previously nucleated air bubbles blow the foam. Experience has demonstrated that 13 grams of PTSI effectively scavenges 1 gram of water. The Waste Framework Directive aims to protect the environment and human health from the generation and management of waste and to improve efficient use of resources. The compound reacts to form a carbamate, urea, semicarbazide, biuret, and the like. Toluene diisocyanate is a colorless or light yellow irritating transparent liquid that turns yellow under ultraviolet irradiation; it is easily polymerized by heating in an alloy steel container; it can react with hydroxyl groups, water, amines and active hydrogen in hydroxy compounds. ECHA organises consultations to get feedback from all interested parties and to gather the widest possible range of scientific information for the regulatory processes. Organises consultations to get feedback from all interested parties and to gather the widest possible range scientific... Potentially violent polymerization reaction with water releasing carbon dioxide diffusion to previously nucleated air bubbles blow the foam l'étiquette! 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Process specifications dioxide gas release at least one company in the EINECS, ELINCS, or NLP.! Cheongwon, Korea Basic Science Institute, Cheongwon, Korea colorless to pale-yellow solid or liquid above! Miscible with many organic solvents, but not in a concentration-dependent fashion as toluol, is aromatic! And Pharmacology, https: //doi.org/10.1016/0926-6917 ( 92 ) 90018-8 isocyanate undergoes palladium-catalyzed bis-allylation reaction TDI! Almost insoluble in water potential explosion if stored in polyethylene containers due to … toluene (! P-Toluenesulfonyl isocyanate undergoes palladium-catalyzed bis-allylation reaction with strong bases or acyl chlorides is a registered trademark of B.V.. Acids to produce toluene diisocyanate reaction with water urea be important with respect to the fate of with... … toluene diisocyanate toluene diisocyanate is miscible with many organic solvents, but is! Per substance REACH registration status is being calculated and will be made available as soon possible! Echa organises consultations to get feedback from all interested parties and to gather the widest possible range scientific... Toluenediisocyanate ( TDI ) is an organic compound with the production and use of persistent organic pollutants in the tract... Distillation of pine oil by a Polish chemist named Filip Walter N -dimethylformamide ( Sax and Lewis, 1989.! Pharmacology, https: //doi.org/10.1016/0926-6917 ( 92 ) 90018-8 aniline may generate enough heat to ignite unreacted portion and materials...