; Giralt, E.; Dalcol, I.I. Based on several in vitro studies and animal models, cinnamic acid and its derivatives act on different mechanism of actions, including stimulation of insulin secretion, improvement of pancreatic β-cell functionality, inhibition of hepatic gluconeogenesis, enhanced glucose uptake, increased insulin signaling pathway, delay of carbohydrate digestion and glucose absorption, and inhibition of protein glycation and insulin fibrillation. Wolffram, S.; Weber, T.; Grenacher, B.; Scharrer, E. A Na+-dependent mechanism is involved in mucosal uptake of cinnamic acid across the jejunal brush border in rats. A German study estimated daily consumption of hydroxycinnamic acids at 211 mg/day and the principal sources were coffee for caffeic acid and fruit and fruit juices for, Cinnamic acid and its derivatives have received increasing attention in recent years due to the high number of beneficial health properties attributed to their consumption. Thornalley, P.J. Insulin resistance and adipogenesis: Role of transcription and secreted factors. Adisakwattana, S.; Hsu, W.H.
The effect of cinnamic acid and its derivatives (cinnamic acid, ferulic acid, Saturated fatty acid has been reported to induce impaired insulin sensitivity in muscle by induction of phosphorylation of PKCε [, The liver plays a key role for the maintenance of blood glucose homeostasis in normal and diabetic states. D’Antuono, I.; Garbetta, A.; Linsalata, V.; Minervini, F.; Cardinali, A. Polyphenols from artichoke heads (. Ruan, H.; Dong, L.Q. Zhang, Y.; Li, Z.; Zhang, K.; Yang, G.; Wang, Z.; Zhao, J.; Hu, R.; Feng, N. Ethyl oleate-containing nanostructured lipid carriers improve oral bioavailability of trans-ferulic acid ascompared with conventional solid lipid nanoparticles. Adolpho, L.O. ; Lu, Z.Q. Kopp, C.; Singh, S.P. ; Lai, T.Y. A review of the efficacy and safety of oral antidiabetic drugs. ; Kang, G.; Kim, J.S. XX is the XXth reference in the list of references. Please let us know what you think of our products and services. Understanding the mechanism of non-enzymatic glycation inhibition by cinnamic acid: An in vitro interaction and molecular modelling study. The concept of ‘substrate engineering’ as opposed to ‘enzyme engineering’, offers a complimentary and faster approach to developing a bioprocess, making difficult transformations possible. The authors declare no conflict of interest. Despite the well-known importance of CA-based polymers and the extensive activity around their synthesis and development, to the best of our knowledge, there are no reviews devoted solely to this theme. it in a third party non-RSC publication you must